Question
I've made strata a few times before, usually for brunches where I have a number of guests coming over and don't want to spend all my time in the kitchen. I always follow instructions in the recipe; I assemble it the night before, refrigerate overnight, and then let it come to room temperature and bake it in the morning.
I've never had any problems, but I'm planning on making this for New Year's brunch that I'm hosting, and I got to thinking about why I need to let the strata come to room temperature before baking it. (Every recipe I've seen for strata says to let it sit on the counter for at least a half an hour.) I bake mine in a glass casserole dish, so I know that one reason for this is to avoid extreme temperature change that could cause the dish to shatter. However, is there any chemistry or physics reason for this - i.e., would baking it (in a disposable aluminum pan, for instance) straight out of the fridge impact the taste/texture?
Answer
My guess - and this is just a (somewhat educated) guess - is that it's just to promote more even cooking.
Since you're talking about a layered dish, some parts are definitely going to cook faster than others. If the entire dish starts from room temperature, as opposed to fridge temperature, then that means less time is required to cook it through. Less time and less heat required to cook means that all of the layers will be more likely to end up at similar internal temperatures - as opposed to having burned bread, liquefied cheese, or rubbery eggs (I'm not sure offhand which cooks the fastest).
Even if it's not an issue with the thermal capacities of your individual ingredients, you're also layering these each several times over, creating a very dense product, so there would still be a significant risk of the middle layers being undercooked, or the outer layers being overcooked.
You might be able to bake it straight out of the fridge; however, you would definitely have to increase the cooking time to account for the temperature difference, and there are a lot of variables that come into play which would affect how evenly it cooks: the intensity and location of your oven's heat source(s), the density of the casserole, the kind of baking dish you use - I probably wouldn't chance it, at least not when preparing this for other people.
You tend to see the same recommendation for anything particularly dense, such as a roast, or anything layered, such as a lasagna, and generally, you do want to follow those recommendations for the same reason. They cook rather poorly if you cook them from cold or frozen, leaving you with a charred surface and an only-mostly-cooked interior. It can still happen even if you start off at room temperature, but it's less likely and the effect tends to be less pronounced.
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